Grey’s Anatomy focuses on young people struggling to be doctors and doctors struggling to stay human. It’s the drama and intensity of medical training mixed with the funny, sexy, painful lives of interns who are about to discover that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.

Meet Meredith Grey. She’s a woman trying to lead a real life while doing a job that makes having a real life impossible. Meredith is a first year surgical intern at Seattle Grace Hospital, the toughest surgical residency program west of Harvard. She and fellow first-year interns Cristina Yang, Izzie Stevens, George O’Malley and Alex Karev were students yesterday. Today they’re doctors and, in a world where on the job training can be a matter of life and death, they’re all juggling the ups and downs of their own personal lives.

The five interns fight to maintain friendships in this most stressful and competitive atmosphere. Meredith’s medical ambition is overshadowed by a troubling secret: Her mother, a noted pioneering surgeon, is suffering from a tragic and devastating illness. Cristina is a study in contradiction; highly competitive and driven, she eschews any favors in order to make it on her own. Isobel "Izzie" Stevens, the small-town girl who paid for medical school by modeling in her underwear, battles for respect amongst her peers. George O’Malley is the warm but insecure boy next door who always manages to do or say the wrong thing - even in the O.R. Worse, in spite of his obvious attraction to Meredith, he’s treated as "just one of the girls." And Alex Karev, the intern every intern loves to hate, masks his working class roots with arrogance and ambition.